With two people, you could each submit two answer cards for more variety each round, and alternate between being the judge. The judge would still pick their favorite answer card and whoever’s card it is would win the round. All of the cure cards would still work while playing with two people except for the social distancing card. If anyone draws that one, they can discard it and draw a different one.
If possible, you could have a third person be the judge over the phone or via Zoom. You would read out the question and answer cards to the judge and they would pick their favorite.
You could also play the game over Zoom with friends or family if they have their own copy. You would just have to modify the rules slightly by appointing a “game master” of each round, in addition to the judge of the round. The judge would pick a question card that everyone else has to answer to, and then everyone else would message the game master with their answer. The game master would then read aloud the answers, and the judge would pick their favorite. The game master can still submit a card for the round, but adding this element would protect the anonymity of everyone’s answers.